Our research is providing paradigm-shifting approaches to overcome those challenges, by blending principles of pathophysiology, biomechanics and mechanical engineering with state-of-the-art materials and robotics. Our work comprises three interrelated streams targeting unmet needs in cardiac (heart) and pulmonary (lung) medicine: (i) augmenting the remaining native function in failing organs/systems to restore functionality, (ii) introducing technologies to replace or repair focal deficits in tissues and deliver therapy and (iii) developing physiologically realistic in vitro, in vivo andin silico  approaches suitable for testing cardiac or pulmonary technologies.